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Using the radial arm water maze (RAWM) with video tracking.

Interesting to see the HVS Image 2100 system being used for radial arm water maze (RAWM) by Nabar et al. (Cell Therapy: A Safe and Efficacious Therapeutic Treatment for Alzheimer’s Disease in APP+PS1 Mice).


The radial arm water maze (RAWM) contains six swim paths or arms extending out of an open central area, with an escape platform located at the end of one arm. This is the goal arm. It seems that the RAWM has the spatial complexity and performance measurement simplicity of the dry radial arm maze combined with the rapid learning and strong motivation observed in the Morris water maze without requiring foot shock or food deprivation as motivating factors.


The origins seem to be in Arendash, King, Gordon, Morgan & Hatcher in 2001 (Progressive, age-related behavioral impairments in transgenic mice carrying both mutant amyloid precursor protein and presenilin-1 transgenes. Brain Res 891: 42–53.) and there is a good write up in Nature Protocols (Alamed et al. "Two-day radial-arm water maze learning and memory task; robust resolution of amyloid-related memory deficits in transgenic mice")

NR Nabar, F Yuan, X Lin, L Wang, G Bai, J Mayl, & Y Li used the
HVS Image Radial Arm Maze Software to track and 
analyze  radial arm water maze (RAWM).



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