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Recent Publications

A few recent publications:

Prenatal stress induces spatial memory deficits and epigenetic changes in the hippocampus indicative of heterochromatin formation and reduced gene expression

JD Benoit, P RakicKM Frick - Behavioural brain research, 2015 - Elsevier
... 1.3. Morris water maze. The water maze consisted of a white circular tank (103 cm in diameter)
filled with water colored white with tempera paint and maintained at 24 ± 2 °C during testing.
Data were recorded using an automated tracking system (HVS Image, Hampton, UK). ...

Simvastatin restored vascular reactivity, endothelial function and reduced string vessel pathology in a mouse model of cerebrovascular disease

XK Tong, E Hamel - Journal of Cerebral Blood Flow & Metabolism, 2015 - nature.com
... Spatial memory was tested in the Morris water maze, as described before. ... These parameters
including the escape latency during the hidden platform training were recorded and analyzed
(2020 Plus tracking system and Water 2020 software, HVS Image, Buckingham, UK). ... 

Neuroinflammation, mitochondrial defects and neurodegeneration in mucopolysaccharidosis III type C mouse model

C Martins, H Hůlková, L Dridi, V Dormoy-Raclet… - Brain, 2015 - Oxford Univ Press
Severe progressive neurological paediatric disease mucopolysaccharidosis III type C is caused by mutations in the HGSNAT gene leading to deficiency of acetyl-CoA: α-glucosaminide N-acetyltransferase involved in the lysosomal catabolism of heparan sulphate. To understand the pathophysiology of the disease we generated a mouse model of mucopolysaccharidosis III type C by germline inactivation of the Hgsnat gene. ...

Urokinase-type plasminogen activator deficiency has little effect on seizure susceptibility and acquired epilepsy phenotype but reduces spontaneous exploration in …

J Rantala, S Kemppainen, XE Ndode-Ekane… - Epilepsy & Behavior, 2015 - Elsevier
... The Morris water maze was used to measure spatial learning and memory. ... A computer connected
to an image analyzer (HVS Image®, Hampton, UK) calculated the escape latency (time between
the start and the end), swim path length, and swimming speed. ...

Chronic up-regulation of the SHH pathway normalizes some developmental effects of trisomy in Ts65Dn mice

T Dutka, D Hallberg, RH Reeves - Mechanisms of development, 2015 - Elsevier
... The improvement in cerebellar structure coincided with an improvement in the performance of
the trisomic mice in the Morris water maze (MWM) (Das et al., 2013), a learning and memory
task linked to hippocampal and cerebellar function (D'Hooge and De Deyn, 2001). ...

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